目的 研究基于非参数检验的统计方法分析化学药品的引湿性与水溶解性之间的关系。方法 采用动态水分吸附分析法测定515种化学药品的吸湿百分率来表征引湿性，并按溶解度试验法测定这些药品的近似溶解度来表征水溶解性，将515种化学药品按水溶解性的不同划分为4水平，通过Kruskal-Wallis和Wilcoxon秩和检验的方法分析化学药品引湿性与水溶解性二者之间的关系。结果 不同水平水溶解性样品的引湿性差异有统计学意义，化学药品的引湿性与其在水中的溶解性呈正相关。结论 从物理性质的角度分析了化学药品的引湿性，为深入研究药物引湿机制奠定了实验基础。
Abstract
OBJECTIVE To analyze the relationship between hygroscopicity and water solubility of chemical drugs by using nonparametric test. METHODS Dynamic vapor sorption (DVS) analysis was adopted to determine the hygroscopicity of 515 chemical drugs, and solubility test method was adopted to determine the water solubility of these drugs. All samples were divided into four levels according to their water solubility, and the relationship between hygroscopicity and water solubility was investigated by using Kruskal-Wallis ＆Wilcoxon rank sum test. RESULTS There were significant differences in the hygroscopicity of drugs with different levels of water solubility, and the hygroscopicity of level 4 was significantly higher than that of level 1. Hygroscopicity was positively correlated with water solubility. CONCLUSION The hygroscopicity of chemical drugs is interpreted in terms of a physical property in this study, and the results provide an experimental foundation for further studies on the mechanism of hygroscopicity.
关键词
引湿性 /
溶解性 /
动态水分吸附 /
化学药品 /
非参数检验 /
Kruskal-Wallis /
Wilcoxon
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Key words
hygroscopicity /
solubility /
dynamic vapor sorption /
chemical drug /
non-parametric test /
Kruskal-Wallis /
Wilcoxon
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中图分类号：
R917
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参考文献
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LI H, YANG X N, DENG M L, et al. Values of nonparametric test in evidence-based medicine practice—correct application of Wilcoxon rank sum test. J Evid Base Med(循证医学), 2009, 9(6):378-380.
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脚注
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基金
国家科技重大专项“重大新药创制”资助项目(2015ZX09303001)
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